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Untreated Wernickes encephalopathy progresses to Korsakoff psychosis, a chronic, largely irreversible memory disorder caused by thiamine-dependent neuronal damage

puffing differently and/or smoking more cigarettes) and the apparent absence of any real health benefit from the addition of a filter tip on a cigarette was noted by Philip Morris as early as 1961 when the Director of Research & Development observed that all too often the smoker who switches to a hi-fi (high filtration) cigarette winds up smoking more units in order to provide himself with the same delivery which he had before 25

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Thus, as P2P meth spread nationwide, an unprecedented event took place in American drug use: Opioid addicts began to shift, en masse, to meth